Piedmont is a census-designated place (CDP) along the Saluda River in Anderson and Greenville counties in the U.S. state of South Carolina. The Greenville County portion of Piedmont is part of the Greenville-Mauldin-Easley Metropolitan Statistical Area, while the Anderson County portion is part of the Anderson Metropolitan Statistical Area.
Piedmont is located in northern Anderson County and southwestern Greenville County at . It is 12 miles south of the center of Greenville. Exit 35 on Interstate 85 is 2 miles to the west of the center of Piedmont.