Powdersville is a census-designated place (CDP) in Anderson County, South Carolina, United States. The population was 7,618 at the 2010 census, up from 5,362 at the 2000 census. For many decades, Powdersville was mainly a farming community. In recent years, many new housing subdivisions and businesses along S.C. Highway 153 have turned Powdersville into a growing suburban area.
According to local legend, the area of Powdersville received its name because the general stores sold gunpowder and the powder could be seen spread about the town. So when entering the town, people would say, "This must be Powdersville."
Another legend about how Powdersville got its name is that the area was used for gunpowder/ammo storage during the Civil War. It was supposedly stored somewhere near the old Powdersville Opry House.
An alternative theory claims that the area was a stopping point for lady travelers to "powder" their nose.
In late 2008, the U.S. Postal Service began allowing "Powdersville" to be used for mail delivery in the 29611 (Greenville), 29642 (Easley) and 29673 (Piedmont) ZIP codes. This is optional. There is a satellite post office in 81 Plaza Shopping Center. While this satellite is technically Piedmont (29673), Powdersville may be used as an address.